Join Professor John Camm and Dr Stuart Connolly in their discussion of the full study publication of the ANNEXA-4 study: Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors.
The ANNEXA-4 trial is a multicentre, prospective, open-label, single-group study of andexanet alfa in patients with acute major bleeding. The study involved over 350 patients and evaluated both the efficacy and safety of andexanet alfa. This 30-minute journal club will explore the insights and impact of the full analysis of the published study ‘Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors’.
View abstract Access full paper
This educational activity is designed for hospitalists, haematologists, interventional cardiologists,
internists/physicians, surgeons, and any other healthcare professional with an interest or role in the
management of patients on anticoagulation with life-threatening bleeds.
After completing this educational activity, participants should be able to:
- Describe the efficacy of andexanet alfa for the reversal of factor Xa inhibitors in patients
presenting with factor Xa inhibitor associated bleeding
- Recall the safety outcomes of andexanet alfa for the reversal of factor Xa inhibitors
Prof John Camm
- Advisor for: Boehringer Ingelheim, Daiichi Sankyo
- Consultant (retained) for: Boehringer Ingelheim
- Received honoraria from: Bayer, Daiichi Sankyo, BMS-Pfizer
Dr Stuart Connolly
- Major research grants, consulting fees and speaker fees from Sanofi-Aventis, Janssen, Pfizer,
Bristol-Myers Squibb, Boehringer Ingelheim, Boston Scientific, Abbott, Bayer
Pharmaceuticals Inc, Portola Pharmaceuticals, Medtronic, Daiichi Sankyo, Servier
Staff and reviewer disclosures
PCM Scientific staff, and others involved with the planning, development, and review of the content for this activity have no relevant affiliations or financial relationships to disclose.
This independent educational activity is supported by funding from Portola Pharmaceuticals Inc.
PCM Scientific is the medical education company acting as scientific secretariat and organiser for this
programme. The activity is run independently of the financial supporter and all content is created by
the faculty. No funder has had input into the content of the activity.